Formulation and evaluation of lipid based solid dispersions of Carvedilol
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چکیده
منابع مشابه
Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions
Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملSolid dispersions of carvedilol with porous silica.
Solid dispersion particles of carvedilol (CAR) were prepared with porous silica (Sylysia 350) by the solvent evaporation method in a vacuum evaporator to ensure an effective pore-filling procedure. Two sets were prepared, each with various amounts of CAR in solid dispersions, and with the pore-filling process differing each time. Set A was prepared by a one-step filling method and set B by a mu...
متن کاملFormulation, Physicochemical Evaluation, and Dissolution Studies of Carbamazepine Solid Dispersions
Carbamazepine is a water-insoluble antiepileptic drug. Being a BCS class-II drug, its absorption is dissolution rate limited. Solid dispersions were prepared to enhance the dissolution rate of the drug. Crospovidone and croscarmellose sodium were used as the hydrophilic carriers. Solid dispersions showed a remarkable enhancement in the dissolution rate of the drug. In the present research work,...
متن کاملformulation & evaluation of oral disintegrating tablets of lamotrigine solid dispersions
lamotrigine is used in the treatment of cns disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. lamotrigine belongs to biopharmaceutical classification systems, bcs class ii (low solubility & high permeability). in addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملPhysical Stability of Carvedilol in Solid Dispersions with Porous Silica
Adsorption onto silica-based high surface area carriers is a long known method of improvement drug dissolution rate, which has been described in early 1970s [1]. Porous silica has many silanol groups on its surface and can be used as pharmaceutical excipient, since it is regarded nontoxic after oral application. Due to its porous structure and large specific surface area, porous silica has a gr...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmacy and Pharmacology
سال: 2020
ISSN: 2455-2674
DOI: 10.31024/ajpp.2020.6.2.2